Clinic-pathological study and comparative analysis of orofacial lesions in a brazilian population of children and adolescents

Objective:To describe the sample of Maxillofacial Complex (MFC) Lesions observed in a Brazilian service diagnostic reference for such lesions, and comparatively analyse observed data across the national and international literature. Material and Methods:Aliterature review of survey of MFC Lesions in Children and Adolescentes was performed. The keywords used were “Oral, Pathology” and “Child”, and 18 articles were selected. Then, we surveyed the biopsy archives of the Department of Pathology and Legal Medicine and the Oral Pathology Laboratory of the Federal University of Ceará recorded from 1994 to 2010. The inclusion criterion was patients whose age fell within the range of 0-16 years old. Results:From a total of 4,775 histological results, 499 (10.4%) were selected.Most lesions were diagnosed in female patients, and the prevalence increased with age. Benign lesions represented 90.4% of those reported; some patients had mucocele and inflammatory lesions, and malignant lesions accounted for 1.8% of all lesions reported. These data, compared to the selected articles, showed little similarity between populations at the international level. Conclusion:the evaluated population had significant differences compared to the articles reviewed. The international level of distribution has little influence on this prevalence, which indicates the necessity for performing more local surveys to establish reliable epidemiological profiles

Modelo experimental de úlcera traumática em mucosa jugal de ratos / Experimental model of traumatic ulcer in the cheek mucosa of rats

PURPOSE: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. METHODS: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a nº 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. RESULTS: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency posttest, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. CONCLUSION: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.

OBJETIVO: Estabelecer um modelo experimental de úlcera traumática em mucosa jugal de ratos para utilização em futuros testes de terapias alternativas. MÉTODOS: Foram utilizados 60 ratos, adultos, machos, pesando entre 250 a 300g. A ulceração na mucosa jugal esquerda foi provocada por meio da abrasão desta com uma lâmina de bisturi número 15. Os animais foram observados por um período de 10 dias, sendo estes pesados e suas escoriações mensuradas. As características histológicas foram analisadas e descritas adotando escores para comparação dos estágios da fase da úlcera. Na análise estatística um valor de p<0,01 foi considerado uma resposta estatisticamente significante em todos os casos. RESULTADOS: Durante os cinco primeiros dias os animais perderam peso ("t" Student - p<0,01). A área da úlcera regrediu linearmente com o tempo, estando quase que completamente cicatrizada ao final de dez dias (ANOVA, pós-teste de Tendência - p<0,0001). Os grupos do 1º, 2º e 3º dias tiveram comportamento semelhante havendo uma diminuição dos escores a partir do 4º dia. CONCLUSÃO: O modelo de úlcera na mucosa jugal de ratos proposto pode ser considerado eficaz, apresentando reprodutibilidade confiável e baixo custo.